Due to the risk of convulsions, emesis should not be induced. In severe cases with a short incubation period, gastric lavage after endo-tracheal intubation may be indicated. Activated charcoal may then be left in the stomach. Convulsions not clinically visible should be managed with diazepam 5 to 10 mg intravenous (IV) bolus, followed by repeated doses every 15 minutes if required, up to 30 mg. In children, 0.25 to 0.4 mg/kg per dose, up to 10 mg/dose. Severe cases should be admitted to the intensive care unit and monitored for convulsions, CNS depression, cardiovascular collapse or gastric hemorrhages. Treatment is symptomatic and no antidote is available. (4)
In cases where marine mammals have been exposed to Domoic Acid Poisoning, treatment involves supportive care as well as control of seizures using agents such as phenobarbital, diazepam, and lorazepam.
Fluids are also given (subcutaneously) to hydrate the animal and maintain normal body function. Many places such as the Marine Mammal Center will treat poisoned animals such as seals.
Due to public health requirements and sea food industries, Domoic Acid detection has been developed using mouse assays and more specific assays based on instrumental methods (such as liquid of gas chromatography) or immunochemical techniques.